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滕俊琳

邮  箱: junlinteng@pku.edu.cn

职  称:教授

办公室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

实验室地址:北京市海淀区颐和园路5号,北京大学,金光生命科学大楼,100871

  • 个人简介
  • 科研领域
  • 代表性论文
  • 实验室简介
      本实验室主要兴趣在于:
1. 微管相关蛋白与神经细胞的极性构建及人类疾病
2. 分子马达与神经细胞内的物质运输
3. 神经系统发育及细胞分化的分子机制

1. Tian X., Zheng P., Zhou, C., Wang, X., Ma, H., Ma, W., Zhou, X., Teng, J*., and Chen J*. (2019). DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy. Accepted.
2. Chen Q., Teng, J., and Chen J. (2019). ATL3, a cargo receptor for reticulophagy (Commentary). Autophagy. doi:10.1080/15548627.2019.1609862.
3. Chen Q., Xiao, Y., Chai, P., Zheng, P., Teng, J*., and Chen J*. (2019). ATL3 is a tubular ER-phagy receptor for GABARAPMediated selective autophagy. Curr Biol. 2019. 29, 846-855.
4. Xia, Y., Huang, N., Chen, Z., Li, F., Fan, G., Ma, D., Chen J*., and Teng J*. (2018). CCDC102B functions in centrosome linker assembly and centrosome cohesion. J Cell Sci. 2018 Dec 3;131(23). pii: jcs222901. doi: 10.1242/jcs.222901.
5. Huang, N., Zhang, D., Wang, S., Teng, J*., and Chen J*. (2018). M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating the localization of CP110-CEP97 complex at the mother centriole. Nat Commu 9:4511 (DOI: 10.1038/s41467-018-06990-9).
6. Zheng, P., Chen, Q., Tian, X., Qian, N., Chai, P., Liu, B., Hu, J. Blackstone, C., Zhu, D., Teng, J*., and Chen J*. (2018). DNA Damage Triggers Tubular Endoplasmic Reticulum Extension to Promote Apoptosis by Facilitating ER-mitochondria Signaling. Cell Res.. 28: 833-854.
7. RESEARCH HIGHLIGHT: Bock FJ, Tait SWG. p53 REEPs to sow ER-mitochondrial contacts. Cell Res. 2018 Sep;28(9):877-878. doi: 10.1038/s41422-018-0073-z.
8. Huang, N., Xia, Y., Zhang, D., Wang, S., He, R., Teng, J*., and Chen J*. (2017). Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Nat Commu 8:15057 (DOI: 10.1038/ncomms15057).
9. Xu, S., Xu, Y., Chen, L, Fang, Q., Song, S., Chen, J*., and Teng, J*. (2017). RCN1 suppresses ER stress-induced apoptosis via calcium homeostasis and PERK–CHOP signaling. Oncogenesis 6 (doi:10.1038/oncsis.2017.6).
10. Zhou, H., Wang T., Zheng, T., Teng, J*., and Chen, J*. (2016). Cep57 is a MIs12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nat Commu 7:10151 (DOI: 10.1038/ncomms10151).
11. Chen, L., Xu, S., Xu, Y., Lu, W., Liu, L., Yue, D., Teng, J*., and Chen, J*. (2016). Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling. Oncogene 35, 35-46.
12. Lv, K., Chen, L., Li, Y., Li, Z., Zheng, P., Liu, Y., Chen, J*., and Teng, J*. (2015). Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci 35, 2559-2571.
13. Wang, Q., Shen, B., Chen, L., Zheng, P., Feng, H., Hao, Q., Liu, X., Liu, L., Xu, S., Chen, J*., and Teng, J*. (2015) Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene 34, 1006-1018.
14. Chen, L., Xu, S., Liu, L., Wen, X., Xu, Y., Chen, J*., and Teng, J*. (2014). Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Cell Death Dis 5, e1219.
15. Wang, Q., Shen, B., Zheng, P., Feng, H., Guo, Y., Cao, W., Chen, L., Liu, X., Zhao, G., Xu, S., Shen, W., Chen, J*., and Teng, J*. (2013.) BmCREC is an endoplasmic reticulum (ER) resident protein and required for ER/Golgi morphology. J Biol Chem 288, 26649-26657.
16. Miao, L., Teng, J*., Lin, J., Liao, X., and Chen, J*. (2013.) 14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments. J Cell Sci 126, 427-436.
17. He, R., Wu, Q., Zhou, H., Huang, N., Chen, J*., and Teng, J*. (2013). Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. J Biol Chem 288, 14384-14390.
18. He, R., Huang, N., Bao, Y., Zhou, H., Teng, J*., and Chen, J*. (2013). LRRC45 is a centrosome linker component required for centrosome cohesion. Cell Rep 4, 1100-1107.
19. Feng, H., Chen, L., Wang, Q., Shen, B., Liu, L., Zheng, P., Xu, S., Liu, X., Chen, J., and Teng, J*. (2013). Calumenin-15 facilitates filopodia formation by promoting TGF-beta superfamily cytokine GDF-15 transcription. Cell Death Dis 4, e870.
20. Wu, Q., He, R., Zhou, H., Yu, A. C., Zhang, B., Teng, J*., and Chen, J*. (2012). Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Cell Res 22, 1390-1401.
21. Liu, Y., Lv, K., Li, Z., Yu, A. C., Chen, J*., and Teng, J*. (2012). PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem 287, 39911-39924.
22. Wang, Q., Teng, J*., Shen, B., Zhang, W., Guo, Y., Su, X., Zhang, C., Yu, A. C., and Chen, J*. (2010). Characterization of kinesin-like proteins in silkworm posterior silk gland cells. Cell Res 20, 713-727.
23. Teng, J., Rai, T., Tanaka, Y., Takei, Y., Nakata, T., Hirasawa, M., Kulkarni, A. B., and Hirokawa, N. (2005). The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol 7, 474-482.
24. Wong, W-C R., Setou, M., Teng, J., Takei, Y. and Hirokawa, N. (2002). Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA 99, 14500-14505.
25. Harada, A., Teng, J., Takei, Y., Oguchi, K. and Hirokawa, N. (2002). MAP2 is required for PKA anchoring in dendrites and proper PKA signal transduction. J Cell Biol 158, 541-549.
26. Teng, J., Takei, Y., Harada, A., Nakata, T., Chen, J., and Hirokawa, N. (2001). Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol 155, 65-76.
我们致力于细胞增殖、分化,以及个体发育过程中细胞结构与功能的动态变化及其调控机制等方面的研究。特别关注细胞骨架对细胞极性化形态结构以及生命活动过程的组织作用;神经系统的发育与细胞分化;细胞内膜系统的动态行为与信号转导、肿瘤细胞的增殖、细胞自噬和细胞凋亡等的关系。

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